CCR5 polyclonal antibody-抗体-抗体-生物在线

产品名称： CCR5 polyclonal antibody

英文名称： CCR5 polyclonal antibody

产品编号： PAB9833

产品价格： null

产品产地：台湾

品牌商标： Abnova

更新时间： null

使用范围：

亚诺法生技股份有限公司（Abnova)

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Recommend Usage:
Western Blot (0.25-0.5 ug/lmL)
The optimal working dilution should be determined by the end user.

Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

3.
Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1.
Doranz BJ, Lu ZH, Rucker J, Zhang TY, Sharron M, Cen YH, Wang ZX, Guo HH, Du JG, Accavitti MA, Doms RW, Peiper SC.J Virol. 1997 Sep;71(9):6305-14.

Western Blot (Cell lysate)
Western blot analysis using CCR5 polyclonal antibody at 0.5 ug/mL on THP-1 whole cell lysates.

Gene Summary:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq

Other Designations:
C-C chemokine receptor 5,C-C chemokine receptor type 5,CCR5 chemokine receptor,chemokine (C-C) receptor 5,chemokine receptor CCR5,chemr13